Second International Inter-Group Study for Classical Hodgkin Lymphoma in Children and Adolescents

Gender: All
Maximum age: 25 Years
Minimum age: N/A

Inclusion Criteria:

- histologically confirmed primary diagnosis of classical Hodgkin's lymphoma

- patients under 18 years of age on the date of written informed consent. In specialized
Teenage and Young Adult (TYA) units in France, Italy and UK patients up to under 25
years of age can also be enrolled. Lower age limits will be country specific according
to national laws or formal insurance requirements that may preclude very young
patients.

- written informed consent of the patient and/or the patient's parents or guardian
according to national laws

- negative pregnancy test within 2 weeks prior to starting treatment for female patients
with childbearing potential

Exclusion Criteria:

- prior chemotherapy or radiotherapy for other malignancies

- pre-treatment of Hodgkin's lymphoma (except for 7-10 days steroid pre-phase of a large
mediastinal tumour)

- diagnosis of lymphocyte-predominant Hodgkin's lymphoma

- other (simultaneous) malignancies

- contraindication or known hypersensitivity to study drugs

- severe concomitant diseases (e.g. immune deficiency syndrome)

- known HIV-positivity

- residence outside the participating countries where long term follow-up cannot be
guaranteed

- pregnancy and/or lactation

- patients who are sexually active and are unwilling to use adequate contraception
during therapy and for one month after last trial treatment

- current or recent (within 30 days prior to date of written informed consent) treatment
with another investigational drug or participation in another interventional clinical
trial