Angstverhalten während MDMA-ausgelöster Serotoninfreisetzung

Drug: MDMA;Drug: Placebo

Inclusion Criteria:

- Male

- Age between 18 and 50 years.

- Understanding of the German language.

- Understanding the procedures and the risks associated with the study.

- Participants must be willing to adhere to the protocol and sign the consent form.

- Participants must be willing to refrain from taking illicit psychoactive substances
during the study.

- Participants must be willing to drink only alcohol-free liquids and no coffee, black
or green tea, or energy drink after midnight of the evening before the study session,
as well as during the study day.

- Participants must be willing not to drive a traffic vehicle or to operate machines
within 48 h after substance administration.

- Body mass index 18-29 kg/m2.

Exclusion Criteria:

- Chronic or acute medical condition

- Hypertension (>140/90 mmHg) or hypotension (SBP<85 mmHg)

- Current or previous major psychiatric disorder

- Psychotic disorder in first-degree relatives

- Illicit substance use (with the exception of cannabis) of more than 5 times or any
time within the previous month.

- Participation in another clinical trial (currently or within the last 30 days)

- Use of medications that may interfere with the effects of the study medications (any
psychiatric medications)

- Tobacco smoking (>10 cigarettes/day)

- Consumption of alcoholic standard drinks (>10/week or >120 g ethanol/week)