PIONEER III: Studie an Patienten mit Herzkranzgefässkrankheit oder einer Herzkreislauferkrankung.

Device: BuMA Supreme DES;Device: Xience or Promus DES

Inclusion Criteria:

1. The patient is a male or non-pregnant female =20 years of age.

2. The patient has symptomatic ischemic heart disease, including chronic stable angina
(and/or objective evidence of myocardial ischemia on functional study or invasive
fractional flow reserve [FFR] measurement) or acute coronary syndromes (UA or NSTEMI),
that requires elective or urgent percutaneous coronary intervention (PCI).

3. The patient is an acceptable candidate for percutaneous coronary intervention (PCI)
with drug-eluting stents, and for emergent coronary bypass graft (CABG) surgery.

4. The patient is willing to comply with specified follow-up evaluations.

5. The patient or legally authorized representative has been informed of the nature of
the study, agrees to its provisions, and has been provided written informed consent
approved by the appropriate Institutional Review Board (IRB) or Ethics Committee (EC).

Exclusion Criteria:

1. Pregnant or nursing patients and those who plan pregnancy in the period up to 1 year
following index procedure. Female patients of childbearing potential must have a
negative pregnancy test done within 7 days prior to index procedure per site standard
test.

2. Patients with a history of bleeding diathesis or coagulopathy, contraindications to
anti-platelet and/or anticoagulant therapy, or who will refuse transfusion.

3. Patients who are receiving or will require chronic anticoagulation therapy for any
reason.

4. Known hypersensitivity or contraindication to aspirin, heparin/bivalirudin, ADP
receptor antagonists (clopidogrel, prasugrel, ticagrelor, ticlopidine), cobalt
chromium, 316L stainless steel or platinum, sirolimus or its analogues, and/or
contrast sensitivity that cannot be adequately pre-medicated.

5. ST-segment elevation myocardial infarction (STEMI) at index presentation or within 7
days prior to randomization.

6. Known LVEF <30% or cardiogenic shock requiring pressors or mechanical circulatory
assistance (e.g., intra-aortic balloon pump, left ventricular assist device, other
temporary cardiac support blood pump).

7. Renal insufficiency, defined as estimated glomerular filtration rate (eGFR) <30
mL/min/1.73 m2 (by the Modification of Diet in Renal Disease equation or
Cockcroft-Gault formula) or dialysis at the time of screening.

8. Target vessel percutaneous coronary intervention with stent placement in the previous
3 months.

9. Planned elective surgery that would require discontinuation of DAPT within 6 months of
the index procedure.

10. Past or pending heart or any other organ transplant, or on the waiting list for any
organ transplant.

11. Patients who are receiving immunosuppressant therapy, or who have known
immunosuppressive or severe autoimmune disease that will require chronic
immunosuppressive therapy. NOTE: Corticosteroid use is permitted.

12. Known other medical illness or known history of substance abuse that may cause
non-compliance with the protocol, confound data interpretation, or is associated with
a life expectancy of less than 1 year.

13. Current participation in another investigational drug or device study.