Étude de première administration chez l’homme de l’anticorps monoclonal BMS-986218 seul et en association avec le nivolumab chez des patients présentant des tumeurs solides avancées.

Biological: Ipilimumab;Biological: BMS-986218;Biological: Nivolumab

Gender: All
Maximum age: N/A
Minimum age: 18 Years

For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Histologic or cytologic confirmation of a solid tumor that is advanced (metastatic,
recurrent and/or unresectable)

- Eastern Cooperative Oncology Group Performance Status of 0 or 1

- Participants must have received, and then progressed, relapsed, or been intolerant to
at least 2 standard treatment regimens with proven survival benefit in the advanced or
metastatic setting according to tumor type, if such a therapy exists

- Advanced stage cutaneous melanoma who have received standard therapies with proven
survival benefit including prior immunotherapy with an anti-programmed cell death 1
(anti-PD-1) or anti-programmed death ligand 1 (anti-PD-L1) (For Part 2A)

- Non-small cell lung cancer (NSCLC) (adenocarcinoma or squamous cell carcinoma) who
have received standard therapies with proven survival benefit including prior
immunotherapy with an anti-PD-1 or anti-PD-L1 (For Parts 2B & 2C)

- Microsatellite Stable Colorectal Cancer (MSS CRC) who have received standard therapies
with proven survival benefit (Part 2D)

Exclusion Criteria:

- Participants with primary CNS malignancies, or tumors with CNS metastases as the only
site of disease, will be excluded

- Cytotoxic agents, unless at least 4 weeks have elapsed from last dose of prior
anti-cancer therapy and initiation of study therapy

- Prior anti-cancer treatments such as chemotherapy, radiotherapy, hormonal, or
immunotherapy (including anti-PD-1/PD-L1) are permitted

Other protocol-defined inclusion/exclusion criteria apply