“Neurobiologische Grundlagen der Impulsivität bei Entscheidungsfindung”, Original study title: “Neurobiological basis of impulsivity in motivated decision-making”

Group 1: Escitalopram, 15mg single dose; Sub-Arm 1 is a functional magnetic resonance imaging (fMRI) study in 50 healthy young adult male volunteers; Sub-Arm 2 is an electroencephalography (EEG) study in 50 healthy young adult male volunteers.

Each subject receives in addition a structrual MRI scan, ECG, personality questionnaires, blood plasma metabolite and genetic testing.
Group 2: Each subject serves as their own control through a counterbalanced, placebo-controlled (ingredient lactose) design.

Gender: Male
Maximum age: 40 Years
Minimum age: 18 Years
Inclusion criteria: ? Age from 18 to 40 years
? Male sex
? European ancestry
? Right-handedness
? Written informed consent
? Consent to adhere to the study protocol
? Ability to adhere to the study protocol
Exclusion criteria: ? Serious past or present brain disease, brain injury or brain surgery
? Any neurological or psychiatric disorders (past or present)
? Nicotine/tobacco use of more than 10 cigarettes per week, or equivalent
? Current use of recreational drugs
? History of alcohol and/or drug abuse
? Any current severe medical condition
? Currently taking medication of any kind
? Allergy to lactose (placebo) or to escitalopram
? Tachycardia >100 bpm, cardiac arrhythmia and/or QTc time >430 ms
? History of severe kidney or liver disorder
? Pacemaker, neurostimulator or any other head or heart implants
? Any breathing difficulties
? Claustrophobia
? Dependence on a hearing aid
? Bald head or dreadlocks (EEG only)
? Inability to sit still (EEG) or lie still (MRI) for the duration of the experiment (sneezing, coughing,
itching, trembling, twitching, pain, etc.)
? Subjects with MRI-incompatible metal parts in the body
? Possibility of the presence of any metal fragments in the body (e.g., metal splinters, ballistic
wounds, shrapnel or surgical clips)