Pulse-UP: Hormone GnRH sur la concentration, l'attention et le langage chez les personnes porteuses d'une trisomie 21 Pulse-UP: GnRH-Hormon auf Konzentration, Aufmerksamkeit und Sprache bei Menschen mit Trisomie 21

Drug: GnRH, gonadorelin acetate;Drug: 0.9% NaCl

Gender: All
Maximum age: 50 Years
Minimum age: 16 Years

Inclusion Criteria:

- Diagnosis of trisomy 21

- Verbal expression (ability to follow the procedures of the study)

- Consent to a non-hormonal contraception during the whole duration of the study For
women: intra-uterine device with copper, a prior tubal ligation or condoms for the
partner For men: condoms or vasectomy

Exclusion Criteria:

- Acute illness (clinical or biochemical findings suggesting acute
illness/hospitalization)

- Chronic alcohol abuse, illicit drug use, anabolic steroid abuse, psychotropic drugs
reported by caregivers

- Taking medication that modifies hormones: spironolactone, ketoconazole,
anticoagulants, corticosteroids, ACTH hormone, psychotropics, including
antidepressants, antipsychotics and anticonvulsants.

- Known pituitary adenoma and other hormone-dependent tumours

- Participation in another clinical study

- Intention to become a parent during the course of the study

- Females: ovarian cysts, non-hypothalamic anovulation (i.e. polycystic ovary syndrome),
pregnancy or lactation

- Males: hematocrit > 54%

- Contraindications for MRI (e.g. pacemaker, metal clips,etc)

- Participant or his/her legal representative do not want to be informed in case of
incidental findings