Investigation des bases neuronales de l'épilepsie au moyen de micro-électrodes chez les patients candidats à une chirurgie de l'épilepsie (IN-MAP)

Device: NeuroPort micro-electrode array

Inclusion Criteria:

- Patient 18 years old or older

- Patient who suffers from potentially surgically remediable drug-resistant focal
epilepsy

- Patient in whom neocortical resective surgery is deemed likely

- Patient who requires evaluation with intracranial subdural EEG electrodes

- Patient in whom a cortical area that is not eloquent (i.e. not involved in a critical
neurological function like language or motor control) is deemed highly likely to be
involved in seizure onset or propagation and is therefore an appropriate site for the
implantation of the micro-electrode array

- Patient who is able and willing to provide informed consent

Exclusion Criteria:

- Patient in whom neocortical resective surgery is deemed unlikely (e.g. patients in
whom a corpus callosotomy or another palliative epilepsy surgery procedure is planned)

- Patient who will be investigated with stereo-EEG electrodes only (these patients will
not undergo a craniotomy for clinical purposes, and implantation of the
micro-electrode array is therefore impossible)

- Patient whose epileptic seizures cause hypermotor or violent motor behavior (due to
the risk of MD mechanical failure and related injury)

- Patient with a previous history of bacterial meningitis (due to the risk of thickening
of the arachnoid membrane complicating the implantation of the micro-electrode array)

- Patient with severe psychiatric disease or psychological distress

- Patient with severe concomitant medical disease (including, but not limited to,
cardiovascular disease, respiratory illness, renal failure, hepatic dysfunction, etc.)

- Patient with known compromise of the immune system caused by a medical condition or
the chronic consumption of immunosuppressant medication (due to the increased risk of
infection; this includes diabetes mellitus)

- Patient with colonization with methicillin-resistant Staphylococcus aureus (due to the
increased risk of difficult-to-manage infection)

- Patient with known tendency for increased bleeding (due to the increased risk of
hemorrhage)

- Patient with an implanted intracranial stimulator, vagus nerve stimulator, or cochlear
implant that will remain active during the study (due to the potential for
interference with the micro-electrode recordings)

- Women who are pregnant or breastfeeding during the study