Eine erstmals am Menschen durchgeführte Studie zur Evaluierung der Sicherheit, Verträglichkeit, Pharmakokinetik (was der Körper mit dem Medikament macht) und Pharmakodynamik (was das Medikament mit dem Körper macht) von dem Prüfmedikament RO7293583 bei Teilnehmern mit inoperablem, Tyrosinase-verwandtem Protein-1 (TYRP1) positivem metastasiertem Melanom.

Drug: RO7293583;Drug: Tocilizumab;Drug: Obinutuzumab;Drug: Adalimumab

Inclusion Criteria:

- Participants with unresectable stage III or stage IV cutaneous melanoma or
participants with unresectable, metastatic uveal or mucosal melanoma for whom SOC is
not available or who are intolerant or non-amenable to SOC.

- Participants with cutaneous melanoma need to have known BRAF status.

- Radiologically measurable disease according to Response Evaluation Criteria in Solid
Tumors (RECIST) v1.1.

- Availability of a representative tumor specimen that is suitable for determination of
TYRP1 status by means of central testing.

- For participants in Part II, willingness to provide mandatory on-treatment biopsies.

- Life expectancy (in the opinion of the Investigator) of =12 weeks.

- Eastern Cooperative Oncology Group (ECOG) performance status 0-1.

- Absence of rapid disease progression, threat to vital organs or non-irradiated lesions
> 2 cm in diameter at critical sites.

- All acute toxic effects of any prior radiotherapy, chemotherapy, targeted or
checkpoint inhibitor therapy, or surgical procedure must have resolved to Grade =1 or
returned to baseline, except for alopecia (any grade), for Grade 2 clinically
controlled sequelae of immune-related toxicities related to checkpoint inhibitor
therapy like adrenal insufficiency and hypopituitarism, and for Grade 2 peripheral
neuropathy.

- Adequate hematological, liver and renal function.

Exclusion Criteria:

- Participants with a history or clinical evidence of central nervous system (CNS)
primary tumors or metastases including leptomeningeal metastases unless they have been
previously treated, are asymptomatic, and have had no requirement for steroids or
enzyme-inducing anticonvulsants in the last 14 days before screening.

- Participants with another invasive malignancy in the last 2 years.

- Active, acute, or chronic inflammatory diseases of the skin affecting more than 5% of
the body surface area. History of Stevens-Johnson syndrome, toxic epidermal
necrolysis, or drug rash with eosinophilia and systemic symptoms.

- Participants with defects in the Bruch's membrane of the eye or at risk of such
defects. Participants with a history of recurrent uveitis or medical conditions that
are associated with frequent uveitis.

- History of or existing damage to inner ear.

- Uncontrolled hypertension.

- Significant cardiovascular disease.

- Known active or uncontrolled bacterial, viral, fungal, mycobacterial, parasitic or
other infection, or any major episode of infection requiring treatment with IV
antibiotics or hospitalization within 4 weeks prior to the start of drug
administration.

- Any other disease, metabolic dysfunction, physical examination finding, or clinical
laboratory finding that contraindicates the use of an investigational drug.

- Major surgery or significant traumatic injury <28 days prior to the first RO7293583
administration or anticipation of the need for major surgery during study treatment.

- Last dose of checkpoint inhibitors, targeted therapies, chemotherapy,
immunostimulating or immunosuppressive therapy or other investigational drug <28 days
prior to the first RO7293583 administration.

- Prior treatment with a T-cell engaging drug

Specific Exclusion Criteria if Pre-treatment with Obinutuzumab is Implemented:

- Known human immunodeficiency virus (HIV)

- History of progressive multifocal leukoencephalopathy.

- Active Tuberculosis (TB) requiring treatment within 3 years prior to baseline.

- Latent TB diagnosed during Screening.

- Positive test results for human T-lymphotropic virus 1.

Specific Exclusion Criteria if Pre-treatment with Adalimumab is Implemented:

- History of untreated tuberculosis or untreated active infection with mycobacterium
tuberculosis.

- Known hypersensitivity to any of the components of adalimumab.