Descrizione riassuntiva della sperimentazione (Fonte di dati: BASEC)
Das Ziel der Studie ist es festzustellen, ob Ocrelizumab die Verschlechterung der Anzeichen und Symptome der MS im Frühstadium zum Stillstand bringt.
In dieser Studie wird den Patienten Ocrelizumab in Form von intravenösen Infusionen verabreicht. Die Studie dauert etwa 6 Jahre. Ungefähr 600 Patienten werden weltweit an dieser Studie teilnehmen, davon ungefähr 20 in der Schweiz.
Malattie studiate(Fonte di dati: BASEC)
SCHUBFÖRMIG REMITTIERENDE MULTIPLE SKLEROSE IM FRÜHSTADIUM
Health conditions
(Fonte di dati: WHO)
Multiple Sclerosis, Relapsing-Remitting
Malattia rara
(Fonte di dati: BASEC)
No
Interventi esaminati (p. es. medicamento, terapia, campagna)
(Fonte di dati: BASEC)
Die erste Dosis Ocrelizumab wird in Form von zwei intravenösen Infusionen mit je 300 mg im Abstand von 14 Tagen verabreicht, jede in einer Lösung aus 250 ml Natriumchlorid 0,9 %. Nach der ersten Ocrelizumab Dosis erhalten die Patienten 600 mg Ocrelizumab in einer Lösung aus 500 ml Natriumchlorid 0,9% im Abstand von 24 Wochen und über einen Zeitraum von bis zu 168 Wochen (insgesamt 8 vollständige Dosisgaben). Im Abstand von 24 Wochen wird die Wirksamkeit und Sicherheit beurteilt.
Interventions
(Fonte di dati: WHO)
Drug: Ocrelizumab
Criteri per la partecipazione alla sperimentazione
(Fonte di dati: BASEC)
- Alter zwischen 18 und einschliesslich 55 Jahre
- Diagnose einer schubförmig remittierenden Multiplen Sklerose nach den 2010 geänderten McDonald-Kriterien
-Krankheitsdauer von ≤3 Jahren seit dem ersten dokumentierten klinischen Schub in Zusammenhang mit MS
-Innerhalb der letzten 12 Monate: Ein oder mehrere klinisch dokumentierte(r)Schub/Schübe ODER Ein oder mehrere Anzeichen von MRI Aktivität
Criteri di esclusione
(Fonte di dati: BASEC)
-Sekundär-progrediente MS oder Vorgeschichte einer primär-progredienten oder schubförmig progredienten MS
-Undurchführbarkeit einer MRT-Untersuchung
-Bekanntsein von anderen neurologischen Beeinträchtigungen
Inclusion/Exclusion Criteria
(Fonte di dati: WHO)
Gender: All
Maximum age: 55 Years
Minimum age: 18 Years
Inclusion Criteria:
- Have a definite diagnosis of RRMS, as per the revised McDonald 2010 criteria
- Have a length of disease duration, from first documented clinical attack consistent
with MS disease of less than or equal to (=) 3 years
- Within the last 12 months one or more clinically reported relapse(s) or one or more
signs of MRI activity
- EDSS of 0.0 to 3.5 inclusive, at screening
- An agreement to use an acceptable birth control method for women of childbearing
potential, during the treatment period and for at least 6 months or longer after the
last dose of study drug
Exclusion Criteria:
- Secondary progressive multiple sclerosis or history of primary progressive or
progressive relapsing MS
- Inability to complete an MRI
- Known presence of other neurological disorders
Exclusions Related to General Health:
- Pregnancy or lactation
- Participants intending to become pregnant during the study or within 6 months after
the last dose of the study drug
- Any concomitant disease that may require chronic treatment with systemic
corticosteroids or immunosuppressants during the course of the study
- History or currently active primary or secondary immunodeficiency
- Lack of peripheral venous access
- History of severe allergic or anaphylactic reactions to humanized or murine monoclonal
antibodies
- Significant or uncontrolled somatic disease or any other significant disease that may
preclude participant from participating in the study
- Congestive heart failure (New York Heart Association III or IV functional severity)
- Known active bacterial, viral, fungal, mycobacterial infection or other infection,
(excluding fungal infection of nail beds) or any major episode of infection requiring
hospitalization or treatment with IV antibiotics within 4 weeks prior to screening or
oral antibiotics 2 weeks prior to screening
- History of malignancy, major opportunistic infections, alcohol or drug abuse,
recurrent or chronic infection, and/or coagulation disorders
Exclusions Related to Medications:
- Received any prior approved disease modifying treatment (DMT) with a label for MS, for
example, interferons, glatiramer acetate, natalizumab, alemtuzumab, daclizumab,
fingolimod, teiflunomide and dimethylfumarate
- Receipt of a live vaccine or attenuated live vaccine within 6 weeks prior to the
baseline visit
- Previous treatment with B-cell targeted therapies (i.e., rituximab, ocrelizumab,
atacicept, belimumab, or ofatumumab)
- Any previous treatment with immunosuppressants/ immunomodulators/ antineoplastic
therapies (cyclophosphamide, azathioprine, mycophenolate mofetil, cyclosporine,
methotrexate, cladribine, mitoxantrone, laquinimod, total body irradiation, or bone
marrow transplantation)
- Treatment with investigational DMT
- Treatment with fampridine/dalfamipridine unless on stable dose for >/=30 days prior to
screening
Exclusion related to Shorter Infusion Substudy:
- Any previous serious IRRs experienced with ocrelizumab treatment
-
Altre informazioni sulla sperimentazione
Stato di reclutamento
Completed
Titolo scientifico
(Fonte di dati: WHO)
An Open-Label, Single-Arm Study to Evaluate the Effectiveness and Safety of Ocrelizumab in Patients With Early Stage Relapsing Remitting Multiple Sclerosis
Tipo di sperimentazione
(Fonte di dati: WHO)
Interventional
Disegno della sperimentazione
(Fonte di dati: WHO)
Allocation: N/A. Intervention model: Single Group Assignment. Primary purpose: Treatment. Masking: None (Open Label).
Fase
(Fonte di dati: WHO)
Phase 3
Punti finali primari
(Fonte di dati: WHO)
Time to Onset of Confirmed Disability Progression (CDP) Sustained for at Least 24 and 48 Weeks, As Measured Using Expanded Disability Status Scale (EDSS);Percentage of Participants With Confirmed Disability Improvement (CDI) at Year 1, As Measured Using EDSS;Percentage of Participants With CDP Sustained for At Least 24 and 48 Weeks at Year 1, As Measured Using EDSS;Percentage of Participants With CDI at Year 2, As Measured Using EDSS;Percentage of Participants With CDP Sustained for At Least 24 and 48 Weeks at Year 2, As Measured Using EDSS;Percentage of Participants With CDI at Year 4, As Measured Using EDSS;Percentage of Participants With CDP Sustained for At Least 24 and 48 Weeks at Year 4, As Measured Using EDSS;Percentage of Participants Who Have Improved, Stable, or Worsened Disability Compared to Baseline at Year 1, As Measured Using EDSS;Percentage of Participants Who Have Improved, Stable, or Worsened Disability Compared to Baseline at Year 2, As Measured Using EDSS;Percentage of Participants Who Have Improved, Stable, or Worsened Disability Compared to Baseline at Year 3, As Measured Using EDSS;Percentage of Participants Who Have Improved, Stable, or Worsened Disability Compared to Baseline at Year 4, As Measured Using EDSS;Mean Change From Baseline in EDSS Score at Week 24;Mean Change From Baseline in EDSS Score at Week 48;Mean Change From Baseline in EDSS Score at Week 72;Mean Change From Baseline in EDSS Score at Week 96;Mean Change From Baseline in EDSS Score at Week 120;Mean Change From Baseline in EDSS Score at Week 144;Mean Change From Baseline in EDSS Score at Week 168;Mean Change From Baseline in EDSS Score at Week 192;Time to First Protocol-Defined Event of Disease Activity;Time to First Relapse;Annualized Relapse Rate;Proportion of Participants with Infusion Related Reactions (IRRs) Occurring During or Within 24 Hours Following the First Infusion After Randomization to the Shorter Infusion Substudy
Punti finali secondari
(Fonte di dati: WHO)
Percentage of Participants Who Are Relapse Free;Percentage of Participants With No Evidence of Protocol Defined Disease Activity;Percentage of Participants With no Evidence of Progression (NEP);Percentage of Participants With no Evidence of Progression Sustained for At Least 24 Weeks and no Active Disease (NEPAD);Change from Baseline in Multiple Sclerosis Functional Composite (MSFC) Total Score;Change from Baseline in MSFC Composite Timed 25 Foot Walk Test (T25FW) Score;Change from Baseline in MSFC Composite 9 Hole Peg Test (9HPT) Score;Change from Baseline in MSFC Composite (Paced Auditory Serial Addition Test [PASAT]) Score;Change from baseline in cognitive performance as measured by Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS);Total Number of T1 Gd-Enhancing Lesions as Detected by Brain MRI;Total Number of New and/or Enlarging T2 Lesion as Detected by Brain MRI;Change from baseline in total T1 hypointense lesion volume as Detected by Brain MRI;Total Number of Fluid-Attenuated Inversion-Recovery (FLAIR) Lesion as Detected by Brain MRI;Change From Baseline in Brain Volume as Detected by Brain MRI;Time to Treatment Discontinuation;Employment Status: Work Productivity and Activity Impairment Questionnaire (WAPI) Score;SymptoMScreen Composite Score;Quality of Life: Multiple Sclerosis Impact Scale (MSIS)-29 Questionnaire Score;Percentage of Participants With Adverse Events (AEs) and Serious Adverse Events (SAEs);Proportion of Participants with IRR (overall) in the Shorter Infusion Substudy;Proportion of Participants with IRR By Dose at Randomization in the Shorter Infusion Substudy;Proportion of Participants with IRRs Leading to Treatment Discontinuation in the Shorter Infusion Substudy
Contatto per informazioni
(Fonte di dati: WHO)
Please refer to primary and secondary sponsors
Risultati della sperimentazione
(Fonte di dati: WHO)
Sintesi dei risultati
ancora nessuna informazione disponibile
Collegamento ai risultati nel registro primario
ancora nessuna informazione disponibile
Informazioni sulla disponibilità dei dati dei singoli partecipanti
ancora nessuna informazione disponibile
Siti di esecuzione della sperimentazione
Siti di esecuzione in Svizzera
(Fonte di dati: BASEC)
Basilea, Berna, Lugano, Luzern, San Gallo
Paesi di esecuzione
(Fonte di dati: WHO)
Argentina, Australia, Austria, Belgium, Brazil, Bulgaria, Canada, Croatia, Denmark, Finland, France, Germany, Hungary, Italy, Kuwait, Lebanon, Mexico, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey, United Kingdom, United States
Contatto per maggiori informazioni sulla sperimentazione
Dati della persona di contatto in Svizzera
(Fonte di dati: BASEC)
Clinical Trials
+41 61 715 43 91
switzerland.clinical-research@roche.com
Contatto per informazioni generali
(Fonte di dati: WHO)
Clinical Trials
Hoffmann-La Roche
Contatto per informazioni scientifiche
(Fonte di dati: WHO)
Clinical Trials
Hoffmann-La Roche
Autorizzazione da parte della commissione d’etica (Fonte di dati: BASEC)
Nome della commissione d’etica che rilascia l’autorizzazione (nel caso di studi multicentrici solo la commissione direttiva)
Ethikkommission Nordwest- und Zentralschweiz EKNZ
Data di autorizzazione da parte della commissione d’etica
07.08.2017
Altri numeri di identificazione delle sperimentazioni
Numero di identificazione della sperimentazione della commissione d’etica (BASEC-ID)
(Fonte di dati: BASEC)
2017-00862
Secondary ID (Fonte di dati: WHO)
2016-002937-31
MA30143
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