Phase II-Studie mit oral verabreichtem PQR309 bei Patienten mit refraktärem oder rezidiviertem Lymphom

Drug: PQR309

Inclusion Criteria

1. Histologically confirmed diagnosis* of relapsed or refractory lymphoma, received at
least two prior lines of therapy regardless of transformation status. Patients with
relapsed chronic lymphoid leukemia (CLL) are eligible if they have received one or
more prior lines of any approved standard therapy * archival biopsies may be used if
obtained up to a year prior to enrollment; re-biopsy is strongly recommended if last
biopsy was obtained more than a year ago.

2. Only for patients in the Phase 2 part: At least one measurable nodal or extra-nodal
lesion defined as follows: Clearly measurable (i.e. well-defined boundaries) in at
least two perpendicular dimensions on imaging scan with > 1.5 cm in longest transverse
diameter.

3. Age = 18 years

4. Eastern Cooperative Oncology Group (ECOG) Performance Score of 0-1 (See Appendix 2).

5. Adequate organ system functions defined as:

1. Absolute neutrophil count (ANC) =1.0x109/l

2. Platelets = 75x109/l

3. Haemoglobin = 85g/L

4. Adequate hepatic function, defined as total bilirubin = 1.5 times the upper limit
of normal (ULN) and alanine aminotransferase (ALT) and aspartate aminotransferase
(AST) = 2.5 times ULN

5. Adequate renal function, defined as serum creatinine = 1.5 times ULN

6. Fasting glucose < 7.0 mmol/L

6. Ability and willingness to swallow and retain oral medication.

7. Willingness and ability to comply with the trial procedures

8. Female and male patients with reproductive potential must agree to use effective
contraception from screening until 90 days after discontinuation of PQR309

9. Signed informed consent1.5 cm in longest transverse diameter.

3. Age >18 years 4. Eastern Cooperative Oncology Group (ECOG) Performance Score of 0-1 5.
Adequate organ system functions defined as:

1. Absolute neutrophil count (ANC) >1.0x109/l

2. Platelets > 75x109/l

Exclusion Criteria:

Any of the following conditions precludes enrollment of a patient:

1. Immunosuppression due to:

- Allogeneic hematopoietic stem cell transplant (HSCT)

- Any immune-suppressive therapy within 4 weeks prior to trial treatment start

2. Autologous stem cell transplant within 3 months prior to trial treatment start.

3. Concomitant anticancer therapy (e.g. chemotherapy, radiotherapy, hormonal therapy,
immunotherapy, biological response modifier, signal transduction inhibitors and
steroids (steroids as maintenance for adrenal insufficiency are allowed)).

4. Concomitant treatment with medicinal products that increase the pH (reduce acidity) of
the upper gastrointestinal tract, including, but not limited to, proton-pump
inhibitors (e.g. omeprazole), H2-antagonists (e.g. ranitidine) and antacids. Patients
may be enrolled in the study after a wash-out period sufficient to terminate their
effect (section 11.1.3.7).

5. Use of any investigational drug within 21 days prior to trial treatment start.

6. Patients who experienced National Cancer Institute (NCI) Common Terminology Criteria
For Adverse Events (CTCAE) grade 4 on PI3K/mTOR inhibitors

7. Any major surgery, chemotherapy or immunotherapy within 21 days prior to trial
treatment start.

8. Symptomatic or progressing central nervous system (CNS) involvement. Exception:
Patients with meningeal involvement can be included upon discussion between the
sponsor and the investigator.

9. Persisting toxicities NCI CTCAE =2 related to prior anticancer therapy

10. Presence of gastrointestinal disease or any other condition that could interfere
significantly with the absorption of the study drug.

11. Severe/unstable angina, myocardial infarction or coronary artery bypass within the
last 3 years prior to trial treatment start, symptomatic congestive heart failure New
York Heart Association (NYHA) Class 3 or 4, hypertension BP>150/100mmHg

12. A serious active infection (e.g. chronic active hepatitis) at the time of treatment,
or another serious underlying medical condition that could impair the ability of the
patient to receive treatment.

13. Lack of appropriate contraceptive measures (male and female)

14. Pregnant or lactating women

15. Known HIV infection

16. Significant medical conditions which could jeopardize compliance with the protocol.

17. Uncontrolled diabetes mellitus; patients with controlled diabetes may be enrolled (see
fasting glucose levels in inclusion criteria).