Mobilise-D Studie: Messung von Mobilität mit Bewegungssensoren

Participants will attend a baseline visit and four follow up visits every 6 months (study length is 24 months). Each visit will involve the completion of questionnaires and assessments including:
1. Descriptive measures (i.e. height and weight, living arrangements, smoking and alcohol use and vision)
2. Clinical assessments (i.e. level of function and disability, quality of life, frailty, fall and injury history, medical history, medication, blood pressure, pain, fatigue and muscle/fat mass)
3. Psychological assessments (i.e. brief memory test, fear of falling and depression)
4. Physical assessments (i.e. balance tests, 6-minute walk test and muscle strength)
5. Disease-specific assessments measuring the severity of the participant s health condition
At the end of each visit, participants will be asked to wear a mobility monitor around their waist for 7 days. The monitor will measure several aspects of mobility such as walking speed and step length.

Inclusion criteria: All participants: 1. Adults aged 18 or over 2. Able to walk 4 meters independently with or without walking aids 3. Anticipated availability for repeated study visits over 24 months 4. Ability to consent and comply with any study specific procedures. 5. Willingness to wear the McRobert’s body sensor (DynaPort MoveMonitor) 6. Able to read and write in first language in the respective country PD Cohort: 1. Patients with the clinical diagnosis of PD according to the recent criteria of the Movement Disorder Society 2. Hoehn & Yahr stage I-III. MS Cohort: 1. A diagnosis of MS based on the revised McDonald’s criteria 2. EDSS score of 3.0-6.5. 3. Evidence of confirmed disability progression within the 12 months prior to screening (defined by a 6-month confirmed EDSS increase of 1.0-point for participants if the EDSS score was 3.0 to 5.5 and a 0.5-point if the EDSS score was 6.0 to 6.5). COPD Cohort: 1. Diagnosis of COPD (post-bronchodilator forced expiratory volume in the first second (FEV1) to forced vital capacity (FVC) ratio
Minimum age:
Maximum age:
Sex: Both
Exclusion criteria: All participants: 1. Occurrence of any of the following within 3 months prior to informed consent: myocardial infarction, hospitalization for unstable angina, stroke, coronary artery bypass graft (CABG), percutaneous coronary intervention (PCI), implantation of a cardiac resynchronization therapy device (CRTD), active treatment for cancer or other malignant disease, uncontrolled congestive heart disease (NYHA class >3), acute psychosis or major psychiatric disorders or continued substance abuse. PD Cohort: 1. History consistent with Dementia with Lewy Bodies (DLB), atypical parkinsonian syndromes (including multiple system atrophy or progressive supranuclear palsy, diagnosed according to accepted criteria) 2. Repeated strokes or stepwise progression of symptoms, leading to a diagnosis of ‘vascular parkinsonism’ 3. Drug-induced Parkinsonism MS Cohort: 1. Clinical relapse within 30 days prior to screening and baseline. COPD Cohort: 1. Having undergone major lung surgery (e.g. lung transplant) 2. Current diagnosis of lung cancer 3. Primary respiratory diseases other than COPD 4. Substantial limitations in mobility due to factors other than COPD 5. Lung volume reduction within 6 months before inclusion PFF Cohort: 1. Not able to walk before treatment of hip fracture