Descrizione riassuntiva della sperimentazione (Fonte di dati: BASEC)
Angst ist ein häufiges Symptom psychiatrischer Erkrankungen. Heutige pharmakologische Behandlungen beruhen auf Tiermodellen zum Annäherungs-Vermeidungs-Konflikt, die beim Menschen bisher nicht untersucht wurden. Mit Annäherungs-Vermeidungs-Konflikt bezeichnet man Situationen, in denen ein Tier oder Mensch eine bestimmte Situation gleichzeitig annähern und vermeiden sollte, zum Beispiel weil in der gleichen Situation sowohl Belohnung als auch Bestrafung möglich ist. In dieser Studie soll menschliches Verhalten in einem Computerspiel untersuchen werden, in denen ein Annäherungs-Vermeidungs-Konflikt besteht.
Insgesamt dauert die Studie 4 Jahre, und es sollen in Zürich 600 Personen eingeschlossen werden. Die Studie wird nur in Zürich durchgeführt.
Wir machen diese Studie so, wie es die Gesetze in der Schweiz vorschreiben. Ausserdem beachten wir alle international anerkannten Richtlinien. Die zuständige Kantonale Ethikkommission hat die Studie geprüft und bewilligt.
Malattie studiate(Fonte di dati: BASEC)
Wir untersuchen, wie der Annäherungs- Vermeidungs-Konflikt in einem Computerspiel gelöst wird. Dazu werden wir Reaktionszeiten und Entscheidungen aufzeichnen.
Health conditions
(Fonte di dati: WHO)
Basic psychological mechanisms of resolving goal conflict
Mental and Behavioural Disorders
Basic psychological mechanisms of resolving goal conflict
Malattia rara
(Fonte di dati: BASEC)
No
Interventi esaminati (p. es. medicamento, terapia, campagna)
(Fonte di dati: BASEC)
Hautleitreaktion, EKG, Gesichts-EMG, Atmung, elektrische Stimulation, Computerspiel.
Interventions
(Fonte di dati: WHO)
Of the recruited 600 participants, 60 are selected to play the computer game in one of the ten experimental situations. Throughout the duration of the game psychophysiological control variables are monitored, as well as individual performance within the game.
Experiment 1: In Computer Game 1, participants have to catch diamonds on a grid (approach motivation). At the same time, there is a possibility that a virtual robber might wake up and take away all diamonds that the participant has collected (avoidance motivation). In each game round, one of three robbers representing different probabilities of waking up is present but inactive in a corner of the grid. The behavioural response to different levels of threat is investigated by allowing the probability of an attack to vary across trials. In the beginning of each trial the predator resides inactive in a corner of the grid, while the participant can either start in the same corner (active start) or from a safe place” – a corner where the participant cannot be caught (passive start).
Experiment 2: Computer Game 2 is similar to Computer Game 1, but the grid is reduced to four squares. This forces participants to perform individual actions for collecting diamonds. Individual actions in this game relate to simple Go and No Go responses.
Experiment 3: Computer Game 1 with an additional aversive components (mild electrical stimulation/loud noises).
Experiment 4: Computer Game 2 with an additional aversive components (mild electrical stimulation/loud noises).
Experiment 5: Computer Game 1 with an additional possibility of catching the robber, to assess fight/flight tendencies.
Experiment 6: Computer Game 2 with an additional possibility of catching the robber, to assess fight/flight tendencies.
Experiment 7: Computer Game 1 with an additional possibility of sampling information
Criteri per la partecipazione alla sperimentazione
(Fonte di dati: BASEC)
• Gesunden Personen zwischen 18 und 40 Jahren
• Normale oder korrigierte Sehstärke
• Rechtshänder
Criteri di esclusione
(Fonte di dati: BASEC)
• Medikamenten- oder Drogeneinnahme in den 2 Wochen vor der Studie ausser Antibabypille und gelegentlicher Gebrauch von Schmerzmitteln (vom Aspirintyp, oder Paracetamol)
• klinisch relevante aktuelle Erkrankung
• Erkrankungen der Seele, des Nervensystems, des Immunsystems, und alle Arten andauernder entzündlicher Erkrankungen
• bekannte oder vermutete Abhängigkeit von Alkohol oder Drogen
• Unfähigkeit, die Studienanweisungen zu verstehen oder zu befolgen
• Teilnahme in einer Medikamentenstudie in den 30 Tagen vor bzw. während dieser Studie
• vorherige Teilnahme in dieser Studie
• Verwandtschaft oder Abhängigkeit von einem Mitglied des Studienteams
Inclusion/Exclusion Criteria
(Fonte di dati: WHO)
Inclusion criteria:
1. Informed Consent as documented by signature
2. Aged between 18 and 40 years
3. Normal vision
Exclusion criteria:
1. Reported use of any drugs in the 2 weeks prior to the study with the exception of contraceptive drugs and incidental use of NSARs or paracetamol
2. Reported clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc.)
3. Reported history of psychiatric, neurological, dependence or systemic/rheumatic disease
4. Reported or suspected non-compliance, drug or alcohol abuse
5. Inability to follow the procedures of the study, e.g. due to language problems
6. Participation in a study with investigational drug within the 30 days preceding and during the present study
7. Previous enrolment into the current study
8. Members of the study team and their family members and dependants
-
Altre informazioni sulla sperimentazione
Data di registrazione della sperimentazione
13 ott 2015
Inserimento del primo partecipante
1 dic 2015
Stato di reclutamento
Ongoing
Titolo scientifico
(Fonte di dati: WHO)
Psychological mechanisms of resolving approach-avoidance conflict - a behavioural study
Tipo di sperimentazione
(Fonte di dati: WHO)
Observational
Disegno della sperimentazione
(Fonte di dati: WHO)
Observational cross sectional study (Other)
Fase
(Fonte di dati: WHO)
Not Applicable
Punti finali primari
(Fonte di dati: WHO)
Game performance is measured by the number of tokens collected during the 1-2 hour computer game.
Punti finali secondari
(Fonte di dati: WHO)
The following outcomes are measured continuously while the participant is playing the video game:
1. Skin conductance responses is measured via two electrodes that are placed on the hand
2. Heart rate is measured via electrocardiogramm (ECG)
3. Respiration rate is measured via a distension-sensitive belt around the chest
4. Pupil size is measured with an eye-tracking device
5. Facial EMG is measured via two electrodes below the left eye
Contatto per informazioni
(Fonte di dati: WHO)
University of Zürich (Switzerland)
Risultati della sperimentazione
(Fonte di dati: WHO)
Sintesi dei risultati
ancora nessuna informazione disponibile
Collegamento ai risultati nel registro primario
ancora nessuna informazione disponibile
Informazioni sulla disponibilità dei dati dei singoli partecipanti
ancora nessuna informazione disponibile
Siti di esecuzione della sperimentazione
Siti di esecuzione in Svizzera
(Fonte di dati: BASEC)
Zurigo
Paesi di esecuzione
(Fonte di dati: WHO)
Switzerland
Contatto per maggiori informazioni sulla sperimentazione
Dati della persona di contatto in Svizzera
(Fonte di dati: BASEC)
Bach Dominik
+41443842457
dominik.bach@uzh.ch
Contatto per informazioni scientifiche
(Fonte di dati: WHO)
Dominik
Bach
Psychiatric University Hospital (Psychiatrische Universitätsklinik) Lenggstrasse 31 Postfach 1931
Autorizzazione da parte della commissione d’etica (Fonte di dati: BASEC)
Nome della commissione d’etica che rilascia l’autorizzazione (nel caso di studi multicentrici solo la commissione direttiva)
Kantonale
Ethikkommission Zürich
Altri numeri di identificazione delle sperimentazioni
Secondary ID (Fonte di dati: WHO)
AAAB
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