Stimulation cérébrale profonde de l’hypothalamus latéral afin d’augmenter la fonction motrice de patients souffrant de lésion de la moelle épinière

Procedure: Device implantation

Gender: All
Maximum age: 65 Years
Minimum age: 18 Years

Inclusion Criteria:

- SCI graded as American Spinal Injury Association Impairment Scale (AIS) C or D (able
to walk independently for a few meters with a walker)

- Focal spinal cord disorder caused by trauma

- Minimum 12 months post-injury

- Stable medical, physical and psychological condition as considered by Investigators

- Able to understand and interact with the study team in French or English

- Adequate care-giver support and access to appropriate medical care in patient's home
community

- Must agree to comply in good faith with all conditions of the study and to attend all
required study training and visit

- Must provide and sign Informed Consent prior to any study related procedures

Exclusion Criteria:

- Limitation of walking function based on accompanying (CNS) disorders (i.e., systemic
malignant disorders, cardiovascular disorders restricting physical training,
peripheral nerve disorders)

- History of significant autonomic dysreflexia

- Cognitive/brain damage

- Epilepsy

- Use of an intrathecal baclofen pump

- Any active implanted cardiac device such as pacemaker or defibrillator

- Any indication that would require diathermy

- Increased risk for defibrillation

- Severe joint contractures disabling or restricting lower limb movements

- Hematological disorders with increased risk for surgical interventions

- Congenital or acquired lower limb abnormalities (affection of joints and bone)

- Women who are pregnant (pregnancy test obligatory for woman of childbearing potential)
or breastfeeding

- Lack of safe contraception for women of childbearing capacity

- Spinal cord lesion due to either a neurodegenerative disease or a tumor

- Gastrointestinal ulcers in the last five years

- Known or suspected eye disorders or diseases

- Other clinically significant concomitant disease states (e.g., renal failure, hepatic
dysfunction, cardiovascular disease, etc.)

- Any other anatomic or co-morbid conditions that, in the Investigator's opinion, could
limit the patient's ability to participate in the study or to comply with follow-up
requirements, or impact the scientific soundness of the study results

- Inability to follow the procedures of the study, e.g. due to language problems,
psychological disorders, dementia, etc. of the participant

- Participation in another study with investigational drug within the 30 days preceding
and during the present study

- Enrolment of the investigator, his/her family members, employees and other dependent
persons

- Participation in another locomotor training study

- Refusal to be informed of any finding during the study