STRONG-Studie: Prävention von Stürzen bei Senioren mit hohem Sturzrisiko durch Nahrungsergänzung mit Molkenprotein und Krafttraining

Dietary Supplement: Protein-free Supplement
Dietary Supplement: Protein Supplement
Procedure: Active Exercise
Procedure: Control Exercise

Inclusion Criteria:

- At least 1 of 5 frailty criteria, definition by Linda Fried: 1) weight loss of > 4.5
kg in the last 12 months; 2) reduced grip strength in Martin Vigorimeter test: ? = 64
kPa, ? = 42 kPa; 3) standardized question on exhaustion as published by Fried et al.;
4) gait speed < 1 m/s; 5) 6-minute walk test < 300 meters and/or Injurious (any
injury) low trauma fall in the last 12 months prior to enrollment

- Reduced protein intake defined as a score = 0.5 at item K of the Mini Nutritional
Assessment (MNA)

- Community-dwelling or assisted living

Exclusion Criteria:

- Mini-mental state examination (MMSE) < 24 (inability to follow the study procedures
and give written informed consent)

- Inability to come to the trial centers

- Inability to walk at least 3 meters with or without walking aid

- Severe kidney impairment (Glomerular filtration rate [GFR] < 30 ml/min)

- Inability to follow exercise instruction or inability to take protein powder mixed in
drink or food (test at baseline screening examination)

- Severe gait impairment or diseases with a risk of recurrent falling (due to conditions
such as, e.g. Parkinson's disease/syndrome, Hemiplegia after stroke, symptomatic
stenosis of the spinal canal, polyneuropathy, epilepsy, recurring vertigo, recurring
syncope)

- Major visual or hearing impairment or other serious illness that would preclude
participation (e.g. alcohol abuse, alcoholic disease)

- Inability to read/speak/write in German (necessary to follow instructions incl. STRONG
exercise manual)

- Living in a nursing home

- Contraindication to treatment (e.g. allergy)

- Contraindication to the vitamin D standard of care therapy