Multizentrische, randomisierte, doppelblinde, placebokontrollierte Induktionsstudie zur Beurteilung der Wirksamkeit und Sicherheit von Upadacitinib (ABT-494) bei Patienten mit mittelschwerem bis schwerem aktivem Morbus Crohn, die auf eine vorhergehende Therapie mit Biologika nur unzureichend angesprochen oder diese nicht vertragen haben

Other: Matching placebo for upadacitinib;Drug: upadacitinib

Inclusion Criteria:

- Confirmed diagnosis of CD for at least 3 months prior to Baseline.

- Confirmed diagnosis of moderate to severe CD as assessed by stool frequency (SF),
abdominal pain (AP) score.

- Evidence of mucosal inflammation based on the Simplified Endoscopic Score for Crohn's
disease (SES-CD) on an endoscopy confirmed by a central reader.

- Demonstrated an inadequate response or intolerance to any biologic therapy for
infliximab, adalimumab, certolizumab pegol, vedolizumab, and ustekinumab.

- If female, participant must meet the contraception recommendations.

Exclusion Criteria:

- Participant with a current diagnosis of ulcerative colitis or indeterminate colitis.

- Participant not on stable doses of CD related antibiotics, oral aminosalicylates,
corticosteroids or methotrexate (MTX).

- Participant with the following ongoing known complications of CD: abscess (abdominal
or peri-anal), symptomatic bowel strictures, fulminant colitis, toxic megacolon, or
any other manifestation that might require surgery while enrolled in the study.

- Participant with ostomy or ileoanal pouch.

- Participant diagnosed with conditions that could interfere with drug absorption
including but not limited to short gut or short bowel syndrome.

- Screening laboratory and other analyses show abnormal results.