Health conditions
(Source de données: WHO)
Pulmonary embolism/chronic thromboembolic pulmonary hypertension
Circulatory System
Pulmonary embolism
Interventions (Source de données: WHO)
Patients with confirmed pulmonary embolism are followed up by regular telephone contacts at 6, 12 and 24 months using a standardised dyspnoea questionnaire. If the questionnaire discovers previously unreported symptoms of dyspnoea, patients are invited to the centre for confirmation of dyspnoea and, if confirmed, an echocardiography will be performed.
In case of a suspicion of PH at echocardiography, right heart catheterisation is performed for the confirmation of PH. CTEPH is confirmed if mean pulmonary arterial pressure (mPAP) greater than or equal to 25 mmHg, pulmonary capillary wedge pressure (PCWP) less than 15 mmHg and pulmonary vascular resistance (PVR) greater than or equal to 300 dyn*sec/cm^5 (3.75 Wood units), and additionally if V/Q scan shows a mismatch or imaging of the lung vessels show a pulmonary vessel obstruction. Any other causes of dyspnoea or elevated PH have to be excluded.
Inclusion/Exclusion Criteria
(Source de données: WHO)
Inclusion criteria:
Men and women (no age limitations) with pulmonary embolism within the preceding 4 weeks, demonstrated by:
1. Pulmonary angiography, or
2. Contrast enhanced spiral computed tomography, or
3. High probability lung scintigraphy (perfusion and ventilation imaging)
Exclusion criteria:
1. Confirmed diagnosis of pulmonary arterial hypertension (PAH) or CTEPH before inclusion
2. Pre-existing severe chronic dyspnoea (New York Heart Association [NYHA] grade III or IV) due to other reasons than PE
3. Cancer or other life-threatening disease with a life expectancy less than 6 months
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Plus d’informations sur l’étude
Date d’enregistrement de l’étude
29 juin 2009
Intégration du premier participant
18 mai 2009
Statut de recrutement
Completed
Titre scientifique
(Source de données: WHO)
Multicentre observational screenINg survey for the detection of chronic thromboembolic PUlmonary hyperTensiON (CTEPH) following Pulmonary Embolism
Type d’étude
(Source de données: WHO)
Observational
Conception de l’étude
(Source de données: WHO)
Prospective multicentre observational phase V study (Screening)
Phase
(Source de données: WHO)
Not Applicable
Points finaux primaires
(Source de données: WHO)
Amount of patients who develop symptomatic CTEPH at 6, 12 and 24 months after PE.
Points finaux secondaires
(Source de données: WHO)
1. Comparison of collected baseline data of the patients who developed CTEPH with the baseline data of the patients who did not develop CTEPH within the 2-year period after diagnosis of PE to identify any potential risk factors
2. Comparison of the results of the dyspnoea questionnaire answered by telephone with the dyspnoea evaluation by the investigator at the clinic to test the usefulness of the telephone screening algorithm in medical practice for diagnosing CTEPH after PE
Contact pour informations
(Source de données: WHO)
Swiss Society for Pulmonary Hypertension (Switzerland)
Résultats de l’étude
(Source de données: WHO)
Résumé des résultats
pas encore d’informations disponibles
Lien vers les résultats dans le registre primaire
pas encore d’informations disponibles
Informations sur la disponibilité des données individuelles des participants
pas encore d’informations disponibles
Lieux de réalisation des études
Pays où sont réalisées les études
(Source de données: WHO)
Switzerland
Contact pour plus d’informations sur l’étude
Contact pour des informations scientifiques
(Source de données: WHO)
John-David
Aubert
University Hospital Lausanne Rue du Bugnon
Plus de numéros d’identification d’étude
Secondary ID (Source de données: WHO)
N/A
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