Eine randomisierte, doppelblinde, placebokontrollierte, Studie zum Einfluss von Doxycyclin auf aversives Gedächtnis in Gesunden

Group 1: Vibramycin? Tabs (Doxycyline), 200mg capsule, oral administration, single-dose.

6 experiments will examine whether aversive memories of healthy participants can be influenced by the antibiotic doxycycline. The experiments will be conducted over the time span of several days, however, the medicament will only be taken once, either at the time of memory consolidation or reconsolidation.


Group 2: Placebo Mannitol PhEur (Perlitol 200SD)
200mg capsule, oral administration, single-dose

Gender: All
Maximum age: 40 Years
Minimum age: 18 Years
Inclusion criteria: - Informed Consent as documented by signature
- Age 18 ? 40 years
Exclusion criteria: ? Allergy to doxycycline or to any other ingredient in the named drugs
? Use of any drugs in the 2 weeks prior to the study with the exception of contraceptive drugs and incidental use of NSARs or paracetamol
? Women who are pregnant or breast feeding,
? Intention to become pregnant during the course of the study,
? Lack of safe contraception, defined as: Female participants of childbearing potential, not using and not willing to continue using a medically reliable method of contraception for the entire study duration
? Other clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc.)
? Any history of psychiatric, neurological, addiction, or systemic/rheumatic disease
? Known or suspected non-compliance, drug or alcohol abuse
? Inability to follow the procedures of the study, e.g. due to language problems
? Participation in another study with investigational drug within 30 days preceding and during the present study,
? Previous enrolment into the current study,
? Members of the study team and their family members and dependants
? Regular work in a medical profession
? Life time history of being a victim of interpersonal violence or other potentially traumatic experience, or close relative of a person with such history